Jane Perry, who has carved out a financial services career at KPMG, JP Morgan and AXA before joining Qantas Super in 2012, will leave the fund at the end of the year.
Qantas Super chair Anne Ward said Ms Perry had demonstrate an "unwavering focus on positive outcomes for members" during her tenure.
"Jane has steered Qantas Super strategically through a period of unprecedented regulatory and industry change with care and distinction," Ms Ward said.
"Jane’s many achievements at Qantas Super include the implementation of the Stronger Super suite of initiatives, the successful transition of more than 32,000 member accounts to a new plan administrator, the appointment of an external insurer to provide standard insurance benefits and day-to-day management of insurance claims, and a concerted and coordinated drive to increase member engagement.
"Qantas Super was also named first of 47 funds for its risk-adjusted investment returns for the default option for the last financial year," Ms Ward said.