Lloyd was previously Perpetual group executive for private wealth and retail distribution after he joined 18 months ago from BT Financial Group.
Ryan departed Perpetual after disagreement with the board on the short and long-term business strategy of the company.
"While Mr Ryan had executed some important business improvements after joining Perpetual in February last year, it had become clear that there were differences between Mr Ryan and the board around emphasis and execution of strategy for the immediate and longer term," Perpetual chairman Peter Scott said.
"Over the weekend we agreed to disagree with Chris Ryan on these important issues and that he would leave Perpetual as a result."
Lloyd said that in accepting the chief executive and managing director role he had agreed to three key priorities with the Perpetual board.
"I have agreed with the board that we need to work harder and faster to refine the growth strategy for the business; deliver further meaningful cost reductions; and reinvigorate sales and distribution across the entire business," he said.
